In vitro and in vivo effects of 3-bromopyruvate against Echinococcus metacestodes
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چکیده
منابع مشابه
In vitro activities of benzimidazoles against Echinococcus multilocularis metacestodes.
Alveolar echinococcosis, caused by the larval (metacestode) stage of the tapeworm Echinococcus multilocularis, is a lethal parasitosis of the liver prevalent in the Northern Hemisphere. For chemotherapy the benzimidazole derivatives mebendazole and albendazole were introduced, and their use has resulted in a significant improvement in the survival rates. However, data from experiments with anim...
متن کاملIn vitro parasiticidal effect of Nitazoxanide against Echinococcus multilocularis metacestodes.
When humans serve as inadvertent intermediate hosts for Echinococcus multilocularis, disease (alveolar echinococcosis [AE]) may result from the expanding parasite metacestode in visceral organs, mostly in the liver. Benzimidazole carbamate derivatives such as mebendazole and albendazole are used for chemotherapeutic treatment of AE. However, these treatments are, in most cases, parasitistatic r...
متن کاملIn vitro and in vivo activities of dicationic diguanidino compounds against Echinococcus multilocularis metacestodes.
Alveolar echinococcosis (AE) is a disease predominantly affecting the liver, with metacestodes (larvae) of the tapeworm Echinococcus multilocularis proliferating and exhibiting tumor-like infiltrative growth. For many years, chemotherapeutical treatment against alveolar echinococcosis has relied on the benzimidazoles albendazole and mebendazole, which require long treatment durations and exhibi...
متن کاملIn vitro and in vivo treatment of Echinococcus protoscoleces and metacestodes with artemisinin and artemisinin-derivatives
Institute of Parasitology, Vetsuisse Faculty, University of Berne, Länggass-Strasse 122, CH-3012 Berne, Switzerland Institute of Animal Pathology, Vetsuisse Faculty, University of Berne, LänggassStrasse 122, CH-3012 Berne, Switzerland Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, PO Box, CH-4002 Basel, Switzerland Grupo SALUVET, Departamento de Sanidad Anim...
متن کاملIn vitro and in vivo treatments of echinococcus protoscoleces and metacestodes with artemisinin and artemisinin derivatives.
In vitro treatment of Echinococcus multilocularis and Echinococcus granulosus larval stages with the antimalarials dihydroartemisinin and artesunate (10 to 40 microM) exhibited promising results, while 6 weeks of in vivo treatment of mice infected with E. multilocularis metacestodes (200 mg/kg of body weight/day) had no effect. However, combination treatments of both drugs with albendazole led ...
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ژورنال
عنوان ژورنال: Veterinary Research
سال: 2019
ISSN: 1297-9716
DOI: 10.1186/s13567-019-0710-7